Phenotypes Associated with This Genotype

Genotype
MGI:3842387

• Allelic Composition: Atf2^tm1Sis/Atf2^tm1Sis
• Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Respiration defects of the Atf2^tm1Glm/Atf2^tm1Glm mice

mortality/aging

neonatal lethality, complete penetrance ( J:55657 )

• die shortly after birth

respiratory system

abnormal lung morphology ( J:55657 )

• presence of meconium in the alveoli, indicating that prenatal aspiration of the amniotic fluid containing meconium occurred

• however, histology shows normal architecture of the lung

respiratory failure ( J:55657 )

• severe respiratory distress resulting in death

embryo

abnormal placenta vasculature ( J:55657 )

• network of embryonic vessels and maternal sinuses in the placenta is poorly developed and fibrinoid accumulates around the fetal blood vessels

abnormal placenta labyrinth morphology ( J:55657 )

• number of cytotrophoblasts is lower in the labyrinth region of the placenta, although the size of the region is similar to wild-type

homeostasis/metabolism

cyanosis ( J:55657 )

hypoxia ( J:55657 )

• marker analysis indicates hypoxia in mutants

cardiovascular system

abnormal placenta vasculature ( J:55657 )

• network of embryonic vessels and maternal sinuses in the placenta is poorly developed and fibrinoid accumulates around the fetal blood vessels

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
meconium aspiration syndrome		DOID:11049		J:55657