Phenotypes Associated with This Genotype

Genotype
MGI:3842800

• Allelic Composition: Tg(RP23-65I14)2Jno/?
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:146431 )

N • unlike other epilepsy models, mice do not display ataxia or tremors

absence seizures ( J:146431 )

• mice display frequent stereotyped rhythmic cortical spike-wave discharges

• seizure frequency is increased in mice carrying Tg(RP23-65I14)2Jno compared to mice carrying Tg(RP23-65I14)1Jno

• injection of ethosuximide suppresses seizure activity

cardiovascular system

cardiovascular system phenotype ( J:146431 )

N • despite transgene expression in the heart, basal cardiac rate is not different from controls

nervous system

absence seizures ( J:146431 )

• mice display frequent stereotyped rhythmic cortical spike-wave discharges

• seizure frequency is increased in mice carrying Tg(RP23-65I14)2Jno compared to mice carrying Tg(RP23-65I14)1Jno

• injection of ethosuximide suppresses seizure activity

abnormal CNS synaptic transmission ( J:146431 )

• increase in peak density of T-type calcium current in thalamic neurons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
epilepsy		DOID:1826		J:146431