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Phenotypes Associated with This Genotype
Genotype
MGI:3842801
Allelic
Composition
Tg(RP23-65I14)1Jno/?
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• unlike other epilepsy models, mice do not display ataxia or tremors
• mice display frequent stereotyped rhythmic cortical spike-wave discharges
• seizure frequency is decreased in mice carrying Tg(RP23-65I14)1Jno compared to mice carrying Tg(RP23-65I14)2Jno
• injection of ethosuximide suppresses seizure activity

cardiovascular system
N
• despite transgene expression in the heart, basal cardiac rate is not different from controls

nervous system
• mice display frequent stereotyped rhythmic cortical spike-wave discharges
• seizure frequency is decreased in mice carrying Tg(RP23-65I14)1Jno compared to mice carrying Tg(RP23-65I14)2Jno
• injection of ethosuximide suppresses seizure activity
• increase in peak density of T-type calcium current in thalamic neurons

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
epilepsy DOID:1826 J:146431


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory