behavior/neurological
N |
• unlike other epilepsy models, mice do not display ataxia or tremors
|
• mice display frequent stereotyped rhythmic cortical spike-wave discharges
• seizure frequency is decreased in mice carrying Tg(RP23-65I14)1Jno compared to mice carrying Tg(RP23-65I14)2Jno
• injection of ethosuximide suppresses seizure activity
|
cardiovascular system
N |
• despite transgene expression in the heart, basal cardiac rate is not different from controls
|
nervous system
• mice display frequent stereotyped rhythmic cortical spike-wave discharges
• seizure frequency is decreased in mice carrying Tg(RP23-65I14)1Jno compared to mice carrying Tg(RP23-65I14)2Jno
• injection of ethosuximide suppresses seizure activity
|
• increase in peak density of T-type calcium current in thalamic neurons
|