Phenotypes Associated with This Genotype

Genotype
MGI:3842820

• Allelic Composition: H2^b/H2^g7; Tg(TcraR28,TcrbR28)KRNDim/0
• Genetic Background: involves: C57BL/6 * NOD * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

mitral valve inflammation ( J:275827 )

• mitral valve inflammation begins at 3 weeks of age and by 8 weeks, accumulation of inflammatory cells and interstitial thickening is obvious indicating fibroinflammatory mitral valve disease

• mononuclear phagocytes (macrophages and monocytes) constitute the vast majority of accumulated leukocytes

• frequency of TNF- and IL-6-producing phagocytes in inflamed mitral valve tissue is elevated, indicating an enrichment of cytokine-producing phagocytes within the inflamed mitral valves

• antibody blockade of either TNF or IL-6 beginning at the onset of mitral valve inflammation reduces mitral valve fibrosis and thickening

rheumatoid arthritis ( J:36815 , J:275827 )

• rheumatoid arthritis occurs with disease onset transpiring between 25 and 35 days of age (J:36815)

• arthritis occurrence is established by joint inspection and measure of ankle thickness, and histological confirmation in several mice (J:36815)

cardiovascular system

abnormal mitral valve morphology ( J:275827 )

• mitral valve hydroxyproline content is elevated

thick mitral valve ( J:275827 )

• by 8 weeks of age, mitral valves are fibrotic and thickened

• TNFR2 neutralization with a monoclonal antibody exacerbates mitral valve fibrosis and thickening

• blockade of either VLA-4 or VCAM-1 with monoclonal antibodies attenuates valve fibrosis and thickening

mitral valve inflammation ( J:275827 )

• mitral valve inflammation begins at 3 weeks of age and by 8 weeks, accumulation of inflammatory cells and interstitial thickening is obvious indicating fibroinflammatory mitral valve disease

• mononuclear phagocytes (macrophages and monocytes) constitute the vast majority of accumulated leukocytes

• frequency of TNF- and IL-6-producing phagocytes in inflamed mitral valve tissue is elevated, indicating an enrichment of cytokine-producing phagocytes within the inflamed mitral valves

• antibody blockade of either TNF or IL-6 beginning at the onset of mitral valve inflammation reduces mitral valve fibrosis and thickening

homeostasis/metabolism

increased hydroxyproline level ( J:275827 )

• mitral valve hydroxyproline content is elevated

skeleton

rheumatoid arthritis ( J:36815 , J:275827 )

• rheumatoid arthritis occurs with disease onset transpiring between 25 and 35 days of age (J:36815)

• arthritis occurrence is established by joint inspection and measure of ankle thickness, and histological confirmation in several mice (J:36815)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
mitral valve disease		DOID:61		J:275827
rheumatoid arthritis		DOID:7148	OMIM:180300	J:36815