Phenotypes Associated with This Genotype

Genotype
MGI:3842833

• Allelic Composition: Tg(KRT14-cre)8Brn/0; Tg(KRT5-Akt1*)Jmpa/0; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor morphology ( J:144831 )

• proliferation is increased in oral tumors compared to in Tg(KRT5-Akt1*)Jmpa oral tumors

• the number of blood vessels is enhanced in dysplasias and tumors compared to normal oral epithelia in Tg(KRT5-Akt1*)Jmpa mice

increased carcinoma incidence ( J:144831 )

• mice develop malignant carcinomas in the oral cavity affecting the palate, ventral side of the tongue, and the external and internal sides of the lips unlike in wild-type mice

• mice develop tumors earlier than in mice expressing Trp53

• mice develop lymph node metastases and lung micrometastases from undifferentiated highly aggressive primary tumors

increased squamous cell carcinoma incidence ( J:144831 )

cellular

increased cell proliferation ( J:144831 )

• cell proliferation of nonlesion oral epithelia is greater than in wild-type and Tg(KRT5-Akt1*)Jmpa mice

increased keratinocyte proliferation ( J:144831 )

• oral keratinocyte proliferation is greater than in wild-type cells

integument

increased keratinocyte proliferation ( J:144831 )

• oral keratinocyte proliferation is greater than in wild-type cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
head and neck squamous cell carcinoma		DOID:5520	OMIM:275355	J:144831