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Phenotypes Associated with This Genotype
Genotype
MGI:3843342
cn8
Allelic
Composition		 Braftm1Cpri/Braftm1Cpri
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(Tyr-cre/ERT2)1Lru/0
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Cpri mutation (0 available); any Braf mutation (60 available)
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (66 available)
Tg(Tyr-cre/ERT2)1Lru mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:147434 )
• tamoxifen-treated mice develop multiple tumors unlike Braftm1Cpri/Braftm1Cpri Tg(Tyr-cre/ERT2)1Laru mice that develop single tumors
increased skin tumor incidence ( J:147434 )
• tamoxifen-treated mice develop nevi unlike control mice (either treated with only ethanol or lacking one of the alleles)
increased melanoma incidence ( J:147434 )
• 80% of tamoxifen-treated mice develop melanomas within 12 months
• median latency to develop melanomas in a tamoxifen-treated mouse is 7 months

integument
increased skin tumor incidence ( J:147434 )
• tamoxifen-treated mice develop nevi unlike control mice (either treated with only ethanol or lacking one of the alleles)

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:147434 )
• tamoxifen-treated mice develop multiple tumors unlike Braftm1Cpri/Braftm1Cpri Tg(Tyr-cre/ERT2)1Laru mice that develop single tumors

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory