Phenotypes Associated with This Genotype

Genotype
MGI:3843451

• Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc}
• Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:147728 )

• mice treated with tamoxifen exhibit a dosage and frequency dependent lethality dieing by 16 months unlike in mice lacking cre expression

neoplasm

increased tumor incidence ( J:147728 )

• all mice develop tumors in the juxta-articular region in the limbs with some evidence of calcification

• following tamoxifen treatment, all mice develop tumors in the juxta-articular region in the limbs with some evidence of calcification

increased sarcoma incidence ( J:147728 )

• mice develop synovial sarcomas

• following tamoxifen treatment, mice develop synovial sarcomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
synovial sarcoma		DOID:5485	OMIM:300813	J:147728