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Phenotypes Associated with This Genotype
Genotype
MGI:3843511
cx2
Allelic
Composition		 Dbptm1Schb/Dbptm1Schb
Hlftm1Schb/Hlftm1Schb
Teftm1Schb/Tef+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbptm1Schb mutation (2 available); any Dbp mutation (23 available)
Hlftm1Schb mutation (2 available); any Hlf mutation (17 available)
Teftm1Schb mutation (2 available); any Tef mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
seizures ( J:90854 )
• several seizure-like activities are observed in mutants, however they never develop into generalized epilepsies
absence seizures ( J:90854 )
• several absence-like seizures without any sign of EEG hypoactivity are seen

nervous system
seizures ( J:90854 )
• several seizure-like activities are observed in mutants, however they never develop into generalized epilepsies
absence seizures ( J:90854 )
• several absence-like seizures without any sign of EEG hypoactivity are seen
abnormal brain wave pattern ( J:90854 )
• analysis of sleep EEG of a 12-hour light period shows an increase in slow-wave delta activity and a decrease in theta activity, however this is much less pronounced than in triple homozygous mutants
• activity in all frequency bins greater than 15 Hz (the beta frequency range) is increased in waking mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory