Phenotypes Associated with This Genotype

Genotype
MGI:3843604

• Allelic Composition: Bcl2l1^tm1.1Mam/Bcl2l1^tm1.1Mam; Tg(Ins2-cre)25Mgn/0; Tg(RIP1-Tag)2Dh/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreas tumor incidence ( J:146436 )

• 13 week old mice have a mean of over 4 tumors with an average volume greater than 50 mm³

• there is a significantly higher proportion of encapsulated, non-invasive tumors in these mice compared to Tg(RIP1-Tag)2Dh transgenics (22.8% vs. 4.3%)

endocrine/exocrine glands

increased pancreas tumor incidence ( J:146436 )

• 13 week old mice have a mean of over 4 tumors with an average volume greater than 50 mm³

• there is a significantly higher proportion of encapsulated, non-invasive tumors in these mice compared to Tg(RIP1-Tag)2Dh transgenics (22.8% vs. 4.3%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:146436