Phenotypes for Stat3 Tg(Col1a1-cre)1Kry MGI:3843780 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Stat3^tm1Aki/Stat3^tm2Aki Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm1Aki mutation (6 available); any Stat3 mutation (72 available)
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)
Tg(Col1a1-cre)1Kry mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone structure ( J:144906 )

• bone volume to tissue volume is reduced by half compared to controls

decreased trabecular bone thickness ( J:144906 )

• trabecular number and trabecular thickness are decreased in the tibia by about a third

• trabecular separation is increased by more than a third

abnormal bone ossification ( J:144906 )

• mineral apposition rate and bone formation rate are significantly reduced in these mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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