Analysis Tools
skeleton
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• mice develop RA starting at 8 months of age
• incidence is about 45% between 11 and 15 months of age, and 100% in mice over 16 months of age
• RA includes swelling and redness of the paws and limited mobility of the ankle or wrist joints
• joints have severe synovitis with destructive changes including marked proliferation of the synovium, infiltration of inflammatory cells, fibrin deposits and severe bone destruction
• the elbows and knees are affected symmetrically in many diseased mice and become rigid
• severity scores are significantly higher in female mice than males (13.5 in year-old females versus 9.6 in year-old males)
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osteoporosis
(
J:133059
)
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• osteoporosis is noted around inflamed joints of older mice
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immune system
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• injection with the T cell superantigen SEB does not cause clonal deletion of T-cells bearing Vbeta8 TCR chains as it does in wild-type mice
• inhibition of activation induced cell death by IL-6 is almost three times greater than in wild-type T cells
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• in older mice with arthritis, the frequency of double-negative thymocytes is increased by 40 fold
• this population included B cells, plasma cells and dendritic cells
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• in older mice with arthritis, the frequency of double-positive thymocytes is reduced by 40 fold
• decreases in this population are observed starting at 18 weeks of age before arthritis as set in
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• increased numbers of neutrophils are found in the lymph nodes of mice with arthritis
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• almost all CD4+ T cells bear activation or memory markers
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• there is a three-fold increase in single-positive thymocytes of older mice with arthritis
• increases in this population are observed starting at 18 weeks of age before arthritis as set in
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• IgA levels are slightly elevated in mice one year of age
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• IgG1 levels are slightly elevated in mice one year of age
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• IgG2a levels are slightly elevated in female mice one year of age
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• IgG2b levels are slightly elevated in male mice one year of age
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• T cells from lymph nodes of non-arthritic mice have higher rates of proliferation in response to anti-CD3 treatment than controls
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• thymocytes from 12 week old mice hyper-proliferate in response to anti-CD3 treatment
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• 1 year old mice have elevated levels of rheumatoid factor (Ig class)
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• 1 year old mice have elevated levels of anti-ribonuclear protein antibodies with higher levels found in females
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• 1 year old mice have elevated levels of anti-dsDNA antibodies with higher levels found in females
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• 1 year old mice have elevated levels of anti-ssDNA antibodies with higher levels found in females
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• mice develop RA starting at 8 months of age
• incidence is about 45% between 11 and 15 months of age, and 100% in mice over 16 months of age
• RA includes swelling and redness of the paws and limited mobility of the ankle or wrist joints
• joints have severe synovitis with destructive changes including marked proliferation of the synovium, infiltration of inflammatory cells, fibrin deposits and severe bone destruction
• the elbows and knees are affected symmetrically in many diseased mice and become rigid
• severity scores are significantly higher in female mice than males (13.5 in year-old females versus 9.6 in year-old males)
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hematopoietic system
|
• injection with the T cell superantigen SEB does not cause clonal deletion of T-cells bearing Vbeta8 TCR chains as it does in wild-type mice
• inhibition of activation induced cell death by IL-6 is almost three times greater than in wild-type T cells
|
|
• in older mice with arthritis, the frequency of double-negative thymocytes is increased by 40 fold
• this population included B cells, plasma cells and dendritic cells
|
|
• in older mice with arthritis, the frequency of double-positive thymocytes is reduced by 40 fold
• decreases in this population are observed starting at 18 weeks of age before arthritis as set in
|
|
• increased numbers of neutrophils are found in the lymph nodes of mice with arthritis
|
|
• almost all CD4+ T cells bear activation or memory markers
|
|
• there is a three-fold increase in single-positive thymocytes of older mice with arthritis
• increases in this population are observed starting at 18 weeks of age before arthritis as set in
|
|
• IgA levels are slightly elevated in mice one year of age
|
|
• IgG1 levels are slightly elevated in mice one year of age
|
|
• IgG2a levels are slightly elevated in female mice one year of age
|
|
• IgG2b levels are slightly elevated in male mice one year of age
|
|
• T cells from lymph nodes of non-arthritic mice have higher rates of proliferation in response to anti-CD3 treatment than controls
|
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• thymocytes from 12 week old mice hyper-proliferate in response to anti-CD3 treatment
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endocrine/exocrine glands
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• thymocytes from 12 week old mice hyper-proliferate in response to anti-CD3 treatment
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| rheumatoid arthritis | DOID:7148 |
OMIM:180300 |
J:133059 | |
