Phenotypes Associated with This Genotype

Genotype
MGI:3844311

• Allelic Composition: Apc^tm1Tno/Apc⁺; Tg(CDX2-cre)101Erf/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:126018 )

• 36% (13/36) animals survived to 300 days of observation; 3 died and 20 were euthanized upon signs of distress

growth/size/body

decreased body weight ( J:126018 )

• males show inhibited weight gain after 120 days

neoplasm

increased tumor incidence ( J:126018 )

• mice show around 10 tumors

increased gastrointestinal tumor incidence ( J:126018 )

• an average of 5-8 tumors are found in colon and rectum, wit some tumors being observed in the cecum and distal small intestine

• colorectal tumors may be observed at early time points

• male mice have about 60% more colon tumors than controls

increased mammary adenocarcinoma incidence ( J:126018 )

• a small number of mice also develop mammary tumors

digestive/alimentary system

rectal prolapse ( J:126018 )

• greater than half the animals observed developed rectal prolapse with intermittent bleeding

increased gastrointestinal tumor incidence ( J:126018 )

• an average of 5-8 tumors are found in colon and rectum, wit some tumors being observed in the cecum and distal small intestine

• colorectal tumors may be observed at early time points

• male mice have about 60% more colon tumors than controls

intestinal obstruction ( J:126018 )

• some (3) animals died during the observation period from intestinal obstruction by tumor

hematopoietic system

anemia ( J:126018 )

• mice exhibit mild anemia

decreased hematocrit ( J:126018 )

• mice displaying mild anemia show hematocrits in range of 33 to 35% compared to around 45% in controls

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:126018 )

• a small number of mice also develop mammary tumors

integument

increased mammary adenocarcinoma incidence ( J:126018 )

• a small number of mice also develop mammary tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:126018