Phenotypes Associated with This Genotype

Genotype
MGI:3844324

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:146760 )

• all mice treated with an adenovirus expressing cre die by 6 months of age

neoplasm

increased carcinoma incidence ( J:146760 )

• urinary bladder tumors in Adeno-cre treated mice are of epithelial origins and exhibit features of carcinoma in situ and high-grade invasive carcinoma with areas of transitional cell, squamous, and sarcomatoid carcinoma

increased urinary bladder carcinoma incidence ( J:146760 )

• by 6 months, all mice treated with an adenovirus expressing cre (Adeno-cre) develop large urinary bladder tumors unlike wild-type mice

• by 4 to 6 months, 60% of Adeno-cre treated mice exhibit metastasis in the local lymph nodes, spleen, liver, and diaphragm

• however, treatment of mice with rapamycin following Adeno-cre injection prevents urinary bladder tumor formation

renal/urinary system

increased urinary bladder carcinoma incidence ( J:146760 )

• by 6 months, all mice treated with an adenovirus expressing cre (Adeno-cre) develop large urinary bladder tumors unlike wild-type mice

• by 4 to 6 months, 60% of Adeno-cre treated mice exhibit metastasis in the local lymph nodes, spleen, liver, and diaphragm

• however, treatment of mice with rapamycin following Adeno-cre injection prevents urinary bladder tumor formation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
urinary bladder cancer		DOID:11054	OMIM:109800	J:146760