Phenotypes for Myf6 Pax3 Trp53 MGI:3844658 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6^tm1(cre)Mrc mutation (0 available); any Myf6 mutation (19 available)
Pax3^tm1Mrc mutation (1 available); any Pax3 mutation (50 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased rhabdomyosarcoma incidence ( J:93444 )

• 2 in 5 mice develop an rhabdomyosarcoma by day 75 to 91

muscle

increased rhabdomyosarcoma incidence ( J:93444 )

• 2 in 5 mice develop an rhabdomyosarcoma by day 75 to 91

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alveolar rhabdomyosarcoma		DOID:4051	OMIM:268220	J:93444

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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