Phenotypes Associated with This Genotype

Genotype
MGI:3844880

cn2

• Allelic Composition: Rfx5^tm1Ifo/Rfx5^tm1.1Ifo; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129 * C57BL/6 * C.B-20

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal MHC II cell surface expression on macrophages ( J:67924 )

• only 6.2% of bone marrow derived macrophages express MHC-II on the surface compared to 30% of controls

• incubation with IFN-gamma increases percentage to 19% which is much less than 72% of wild-type macrophages

hematopoietic system

abnormal MHC II cell surface expression on macrophages ( J:67924 )

• only 6.2% of bone marrow derived macrophages express MHC-II on the surface compared to 30% of controls

• incubation with IFN-gamma increases percentage to 19% which is much less than 72% of wild-type macrophages