Phenotypes Associated with This Genotype

Genotype
MGI:3846168

• Allelic Composition: Hba^tm1(HBA)Tow/Hba^tm1(HBA)Tow; Hbb^{tm2(HBG1,HBD,HBB*)Ryan}/Hbb^{tm3(HBG1,HBB)Tow}
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

spleen hyperplasia ( J:148521 )

• spleen as a percentage of bodyweight is slightly increased

hematopoietic system

spleen hyperplasia ( J:148521 )

• spleen as a percentage of bodyweight is slightly increased

abnormal definitive hematopoiesis ( J:148521 )

• hemoglobin proteins are all of human origin

• at birth, blood contains 64% of human gamma globin chains and 36% human beta globin chains

• human beta-globin chain usage increases with age while gamma globin usage drops

• by 8 weeks of age beta-globin usage stabilizes at about 90% while delta and gamma chains make up about 5%

high mean erythrocyte cell number ( J:148521 )

• red blood cell count is about 10% higher than controls

decreased hemoglobin content ( J:148521 )

• hemoglobin content is decreased about 10%

decreased mean corpuscular volume ( J:148521 )

• packed cell volume is slightly decreased

reticulocytosis ( J:148521 )

• percentage of reticulocytes in the blood is increased

growth/size/body

spleen hyperplasia ( J:148521 )

• spleen as a percentage of bodyweight is slightly increased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
beta thalassemia		DOID:12241	OMIM:613985	J:148521