Phenotypes Associated with This Genotype

Genotype
MGI:3846455

• Allelic Composition: Dp(16Cbr1-Fam3b)1Rhr/0
• Genetic Background: involves: 129S6/SvEvTac * C3H/HeSnJ * C57BL/6Ei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased brain weight ( J:148478 )

• at 7.5 months

increased hippocampus volume ( J:148478 )

• the hippocampus volume is enlarged compared to in wild-type mice

thickened cerebral cortex ( J:148478 )

• the motor cortex thicker than in wild-type mice

abnormal dendrite morphology ( J:148478 )

• dendritic spine density in the fascia dentate is decreased 14% compared to in wild-type mice

• the area of spine head in the fascia dentata is increased compared to in wild-type mice

• however, the length of spine necks in the fascia dentate is normal

• the average width of dendrites in layers II to III apical oblique is decreased compared to in wild-type mice

• the area of spine head in layers II to III is increased compared to in wild-type mice

reduced long-term potentiation ( J:148478 )

• tetanization protocols fail to induce long term potentiation (LTP) unlike in wild-type mice

• however, treatment with picrotoxin restores the ability of tetanization to induce LTP

behavior/neurological

abnormal object recognition memory ( J:148478 )

• mice exhibit impaired object recognition compared with wild-type mice

abnormal spatial working memory ( J:148478 )

• mice exhibit inferior performance in a T-maze compared with wild-type mice

increased thigmotaxis ( J:148478 )

• mice spend more time and travel a longer distance in the periphery of an open field compared with wild-type mice

abnormal response to novel object ( J:148478 )

• mice exhibit a lack of interest towards a novel object compared with wild-type mice

decreased vertical activity ( J:148478 )

• during the light cycle, mice spend less time rearing than wild-type mice

• however, other locomotor activities are normal during the light cycle

growth/size/body

increased body weight ( J:148478 )

• at 3 and 3.5 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:148478