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Phenotypes Associated with This Genotype
Genotype
MGI:3849179
Allelic
Composition		 Nf1tm1Fcr/Nf1tm1Fcr
Trp53tm1Elee/Trp53tm1Elee
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Fcr mutation (3 available); any Nf1 mutation (161 available)
Tg(GFAP-cre)25Mes mutation (2 available)
Trp53tm1Elee mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:149662 )
• all mice die prior to 200 days

neoplasm
increased glioma incidence ( J:149662 )
• 70% of gliomas exhibit necrosis, a feature of human glioblastoma multiforme
• tumors are relatively homogeneous histological and in lineage marker expression
decreased tumor latency ( J:149662 )
• all mice develop astrocytic gliomas with shorter latency than observed in Trp53tm1Elee/Trp53tm1Tyj Tg(GFAP-cre)25Mes or Trp53tm1Elee/ Trp53tm1Elee Tg(GFAP-cre)25Mes mice

nervous system
increased glioma incidence ( J:149662 )
• 70% of gliomas exhibit necrosis, a feature of human glioblastoma multiforme
• tumors are relatively homogeneous histological and in lineage marker expression

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
glioblastoma DOID:3068 J:149662

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory