Phenotypes Associated with This Genotype

Genotype
MGI:3849439

• Allelic Composition: Tg(Lck-Tal1)4709Led/0
• Genetic Background: FVB/N-Tg(Lck-Tal1)4709Led

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:36076 )

• median survival is 350 days

neoplasm

increased lymphoblastic lymphoma incidence ( J:36076 )

• mice develop clonal T cell lymphoblastic leukemia/lymphoma

increased leukemia incidence ( J:36076 )

• mice exhibit lymphoblastic infiltrates in the thymus, para-sternal muscle, pericardium, spleen, liver, and kidneys

• mice develop clonal T cell lymphoblastic leukemia/lymphoma

immune system

abnormal thymus morphology ( J:36076 )

• mice develop thymic masses composed of lymphoblastic cells with prominent nucleoli and scant cytoplasm unlike wild-type mice

increased lymphoblastic lymphoma incidence ( J:36076 )

• mice develop clonal T cell lymphoblastic leukemia/lymphoma

enlarged spleen ( J:36076 )

respiratory system

respiratory distress ( J:36076 )

• in mice that develop tumors

liver/biliary system

enlarged liver ( J:36076 )

growth/size/body

weight loss ( J:36076 )

• in mice that develop tumors

enlarged liver ( J:36076 )

enlarged spleen ( J:36076 )

hematopoietic system

abnormal thymus morphology ( J:36076 )

• mice develop thymic masses composed of lymphoblastic cells with prominent nucleoli and scant cytoplasm unlike wild-type mice

increased lymphoblastic lymphoma incidence ( J:36076 )

• mice develop clonal T cell lymphoblastic leukemia/lymphoma

enlarged spleen ( J:36076 )

integument

ruffled hair ( J:36076 )

• in mice that develop tumors

endocrine/exocrine glands

abnormal thymus morphology ( J:36076 )

• mice develop thymic masses composed of lymphoblastic cells with prominent nucleoli and scant cytoplasm unlike wild-type mice

increased lymphoblastic lymphoma incidence ( J:36076 )

• mice develop clonal T cell lymphoblastic leukemia/lymphoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lymphoid leukemia		DOID:1037		J:36076