Phenotypes Associated with This Genotype

Genotype
MGI:3850190

• Allelic Composition: Tg(KRT5-tTA)1216Glk/0; Tg(tetO-Il13)1Tazh/0
• Genetic Background: B6.Cg-Tg(KRT5-tTA)1216Glk Tg(tetO-Il13)1Tazh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

cutaneous mastocytosis ( J:150232 )

• 4-fold in the skin following doxycycline withdrawal

increased IgE level ( J:150232 )

• following doxycycline withdrawal

increased IgG1 level ( J:150232 )

• following doxycycline withdrawal

increased interleukin-13 secretion ( J:150232 )

• following doxycycline withdrawal and stimulation with anti-CD3/CD28, lymphocytes and peripheral blood mononuclear cells produce more IL13 than wild-type cells

increased interleukin-4 secretion ( J:150232 )

• following doxycycline withdrawal, IL4 lymphocyte production is increased compared to in wild-type mice

dermatitis ( J:150232 )

• following doxycycline withdrawal, mice exhibit increased numbers of mononuclear cells and eosinophils infiltrating the subepidermal, intradermal, and perivascular spaces of the skin unlike in wild-type mice

cardiovascular system

increased angiogenesis ( J:150232 )

• following doxycycline withdrawal, mice exhibit an increase in subcutaneous blood vessel formation compared to in wild-type mice

hematopoietic system

cutaneous mastocytosis ( J:150232 )

• 4-fold in the skin following doxycycline withdrawal

increased IgE level ( J:150232 )

• following doxycycline withdrawal

increased IgG1 level ( J:150232 )

• following doxycycline withdrawal

homeostasis/metabolism

epidermal spongiosis ( J:150232 )

• spongiosis following doxycycline withdrawal

integument

dermatitis ( J:150232 )

• following doxycycline withdrawal, mice exhibit increased numbers of mononuclear cells and eosinophils infiltrating the subepidermal, intradermal, and perivascular spaces of the skin unlike in wild-type mice

alopecia ( J:150232 )

• following doxycycline withdrawal

thick dermal layer ( J:150232 )

• following doxycycline withdrawal

hyperkeratosis ( J:150232 )

• following doxycycline withdrawal

thick epidermis ( J:150232 )

• following doxycycline withdrawal

reddish skin ( J:150232 )

• following doxycycline withdrawal

skin lesions ( J:150232 )

• following doxycycline withdrawal, skin lesions progress and become extensive including dry lichenified skin lesions unlike in wild-type mice

abnormal skin condition ( J:150232 )

• following doxycycline withdrawal, mice exhibit skin crusting, excoriation, bacterial pyoderma, and erosions in the skin mostly on the back and abdominal areas unlike wild-type mice

epidermal spongiosis ( J:150232 )

• spongiosis following doxycycline withdrawal

skin fibrosis ( J:150232 )

• following doxycycline withdrawal, mice develop skin fibrosis unlike wild-type mice

increased pruritus ( J:150232 )

• following doxycycline withdrawal, mice exhibit pruritus unlike wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:150232