Phenotypes Associated with This Genotype

Genotype
MGI:3850354

• Allelic Composition: Hr^rh-8J/Hr^rh-8J
• Genetic Background: B10.D2/nSnJ-Hr^rh-8J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

dermal cyst ( J:50909 )

• small, deep dermal cysts

alopecia ( J:50909 )

• loss of periorbital hair at approximately 14 days of age followed by complete loss of hair by 3 weeks of age

absent hair follicle dermal papilla ( J:50909 )

• absent dermal papilla

dilated hair follicle infundibulum ( J:50909 )

• massively dilated follicular infundibulum with laminated cornified material

abnormal hair cycle ( J:50909 )

• at the end of the first catagen phase the dermal papilla fails to follow the contracting follicle and becomes stranded deep in the reticular dermis and results in the formation of utricles and deep dermal cysts

abnormal skin appearance ( J:50909 )

• skin folding

growth/size/body

dermal cyst ( J:50909 )

• small, deep dermal cysts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alopecia universalis		DOID:0050634	OMIM:203655	J:50909
atrichia with papular lesions		DOID:0060689	OMIM:209500	J:50909