Phenotypes Associated with This Genotype

Genotype
MGI:3850394

• Allelic Composition: Nf2^tm1Gth/Nf2^tm2Gth; Tg(Mpz-cre)2Brn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:63264 )

premature death ( J:63264 )

• 50% of mice die within the first year

craniofacial

delayed tooth eruption ( J:63264 )

• retarded or absent

failure of tooth eruption ( J:63264 )

• retarded or absent

growth/size/body

delayed tooth eruption ( J:63264 )

• retarded or absent

failure of tooth eruption ( J:63264 )

• retarded or absent

decreased body size ( J:63264 )

decreased body weight ( J:63264 )

hearing/vestibular/ear

increased susceptibility to otitis media ( J:63264 )

immune system

increased susceptibility to otitis media ( J:63264 )

skeleton

delayed tooth eruption ( J:63264 )

• retarded or absent

failure of tooth eruption ( J:63264 )

• retarded or absent

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:63264