Phenotypes Associated with This Genotype

Genotype
MGI:3850412

• Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn; Nf2^tm2Gth/Nf2^tm2Gth
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased liver tumor incidence ( J:131179 )

• following adenoviral cre treatment, liver tumor development is increased compared to in untreated mice (on average 18% from 3%)

osseous metaplasia ( J:131179 )

• following treatment with adenoviral cre, 15% of mice exhibit osseous metaplasia compared to 2% of wild-type mice

increased meningioma incidence ( J:131179 )

• following treatment with adenoviral cre, meningioma development is increased compared to in untreated mice (on average 37% from 13%)

• meningiomas in adenoviral cre-treated mice share radiological features with human meningiomas

increased osteoma incidence ( J:131179 )

• following treatment with adenoviral cre, osteoma development is increased compared to in untreated mice (on average 78% from 57%)

nervous system

increased meningioma incidence ( J:131179 )

• following treatment with adenoviral cre, meningioma development is increased compared to in untreated mice (on average 37% from 13%)

• meningiomas in adenoviral cre-treated mice share radiological features with human meningiomas

hydrocephaly ( J:131179 )

• following adenoviral cre treatment, hydrocephalus is increased compared to in untreated mice (on average 56% from 36%)

abnormal meninges morphology ( J:131179 )

• following adenoviral cre treatment, meningothelial proliferation is increased compared to in untreated mice (on average 77% from 46%)

skeleton

increased osteoma incidence ( J:131179 )

• following treatment with adenoviral cre, osteoma development is increased compared to in untreated mice (on average 78% from 57%)

liver/biliary system

increased liver tumor incidence ( J:131179 )

• following adenoviral cre treatment, liver tumor development is increased compared to in untreated mice (on average 18% from 3%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial meningioma		DOID:4586		J:131179