About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3850536
Allelic
Composition		 Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
Genetic
Background		 involves: 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation (2 available); any Gfap mutation (48 available)
Tg(GFAP)10Mes mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:146191 )
• all animals die by under 50 days of age (most die around 30 days)

nervous system
abnormal hippocampus morphology ( J:146191 )
• Rosenthal fiber formation is observed

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alexander disease DOID:4252 OMIM:203450
 J:146191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory