neoplasm
• the expansion of a monoclonal B cell population in these mice is indicative of leukemia
|
immune system
• spleen size is increased with age due to the emergence of a monoclonal B cell population
|
• as mice age, a large population emerges of monoclonal B cells preferentially expressing the wild-type allele
• these monoclonal B cells are larger in size and number, and have clumped chromatin with little cytoplasm
|
• as mice age, the number of B cells in the blood increase due to the emergence of a monoclonal population
|
• about 60% of mice with a monoclonal B cell population display lymph node hyperplasia with numbers being up to 15 fold higher
|
hematopoietic system
• spleen size is increased with age due to the emergence of a monoclonal B cell population
|
• as mice age, a large population emerges of monoclonal B cells preferentially expressing the wild-type allele
• these monoclonal B cells are larger in size and number, and have clumped chromatin with little cytoplasm
|
• as mice age, the number of B cells in the blood increase due to the emergence of a monoclonal population
|
growth/size/body
• spleen size is increased with age due to the emergence of a monoclonal B cell population
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
chronic lymphocytic leukemia | DOID:1040 |
OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559 |
J:150315 |