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Phenotypes Associated with This Genotype
Genotype
MGI:3851204
cx4
Allelic
Composition		 Fcer1atm1Knt/Fcer1atm1Knt
Fcer2atm1Max/Fcer2atm1Max
Fcgr1tm1Jsv/Fcgr1tm1Jsv
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic
Background		 B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1atm1Knt mutation (3 available); any Fcer1a mutation (23 available)
Fcer2atm1Max mutation (0 available); any Fcer2a mutation (25 available)
Fcgr1tm1Jsv mutation (4 available); any Fcgr1 mutation (36 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (48 available)
Fcgr3tm1Jsv mutation (5 available); any Fcgr3 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:144620 )
• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally
• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells
abnormal macrophage physiology ( J:144620 )
• macrophages fail to react to IgE complexes
increased susceptibility to type I hypersensitivity reaction ( J:144620 )
• mice fail to initiate an airway inflammatory response when IgE immune complexes are administered intranasally

hematopoietic system
abnormal mast cell physiology ( J:144620 )
• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally
• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells
abnormal macrophage physiology ( J:144620 )
• macrophages fail to react to IgE complexes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory