Phenotypes Associated with This Genotype

Genotype
MGI:3851332

• Allelic Composition: Otc^spf-ash/Y
• Genetic Background: B6EiC3Sn a/A-Otc^spf-ash/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:108979 )

♂ • mutants are unable to locate the hidden platform by day 4 in the Morris water maze compared to wild-type which find it by this time

abnormal spatial reference memory ( J:108979 )

♂ • mutants are unable to locate the hidden platform by day 4 in the Morris water maze compared to wild-type which find it by this time

abnormal spatial working memory ( J:108979 )

♂ • in a two trial Y-maze, mutants show reduced retention memory, unable to distinguish the novel arm from the other two arms

growth/size/body

decreased body size ( J:108979 )

♂ • smaller than mature 6-7 month old wild-type mice

homeostasis/metabolism

increased circulating ammonia level ( J:108979 )

♂

immune system

increased susceptibility to endotoxin shock ( J:108979 )

♂ • mutants are more sensitive to immune challenge with LPS than wild-type, with significant delay in recovery time from sickness

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ornithine carbamoyltransferase deficiency		DOID:9271	OMIM:311250	J:108979