Phenotypes Associated with This Genotype

Genotype
MGI:3851339

cx5

• Allelic Composition: Fgf23^tm1Blan/Fgf23^tm1Blan; Vdr^tm1Rge/Vdr^tm1Rge
• Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:121006 )

N • the homozygous null VDR alleles almost negate the perturbed mineral homeostasis characteristic of mice with homozygote null Fgf23 alleles

increased circulating parathyroid hormone level ( J:121006 )

• PTH levels are elevated (86 pg/ml) in these 4 week old mice fed a high calcium diet

increased circulating alkaline phosphatase level ( J:121006 )

• 4 week old mice have elevated levels of serum alkaline phosphatase compared to wild-type mice

integument

epidermal cyst ( J:121006 )

• epidermal cysts are noticeable at 4 weeks of age

growth/size/body

epidermal cyst ( J:121006 )

• epidermal cysts are noticeable at 4 weeks of age