Analysis Tools
growth/size/body
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• bodyweight of 4 week old mice is less than half that of controls despite being on a diet rich in calcium and lactose
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hematopoietic system
small spleen
(
J:121006
)
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• spleens of 4 week old mice are atrophied compared to controls
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homeostasis/metabolism
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• serum urea levels are twice that of controls when fed a high calcium diet
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hypoglycemia
(
J:121006
)
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• blood sugar levels are about a third lower than controls
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• 9 out of 12 mice have undetectable levels of serum insulin with the 3 other mice having insulin levels well below controls
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• serum calcium levels are elevated (2.97 mmol/l vs. 2.55 mmol/l) when fed a high calcium diet
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• serum phosphorous levels are extremely elevated (3.38 mmol/l vs. 5.06 mmol/l) when fed a high calcium diet
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• mice have levels of serum alkaline phosphatase that are 3-fold higher than controls when fed a high calcium diet
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• serum albumin levels are reduced when mice are fed a high calcium diet
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• mice have 30% less rise in glucose levels after a glucose challenge
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immune system
small spleen
(
J:121006
)
|
• spleens of 4 week old mice are atrophied compared to controls
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respiratory system
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• diffuse calcification of the main bronchus is occasionally observed
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skeleton
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• mice have reduced volumetric bone mineral density of the femoral shaft and femoral metaphysic
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• thinning of mineralized cortical bone
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• mice have reduced volumetric bone mineral density of the femoral shaft and femoral metaphysic and thinning of mineralized cortical bone
• growth plates are normal in these mice, which differentiates this phenotype from rickets
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integument
