Phenotypes Associated with This Genotype

Genotype
MGI:3851802

hm1

• Allelic Composition: Sdc4^tm1Tmu/Sdc4^tm1Tmu
• Genetic Background: B6.129S2-Sdc4^tm1Tmu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:68843 , J:131075 )

• following ip injection of kappa-carrageenan at 75 mg/kg, 7 of 24 (29.2%) of mice die within 7 days compared to none of 24 similarly treated wild-type controls (J:68843)

• increased incidence of death following treatment with concanavalin-A compared to similarly treated wild-type controls (J:131075)

embryo

abnormal placental labyrinth vasculature morphology ( J:65874 )

• at E17.5 degeneration of vessels is more diffuse and occurs over a larger area compared to wild-type controls

homeostasis/metabolism

increased blood urea nitrogen level ( J:68843 )

• on days 1 and 4 following ip injection of kappa-carrageenan at 75 mg/kg, surviving mice exhibit significantly higher BUN levels than similarly treated wild-type controls

increased susceptibility to xenobiotic induced morbidity/mortality ( J:68843 , J:131075 )

• following ip injection of kappa-carrageenan at 75 mg/kg, 7 of 24 (29.2%) of mice die within 7 days compared to none of 24 similarly treated wild-type controls (J:68843)

• increased incidence of death following treatment with concanavalin-A compared to similarly treated wild-type controls (J:131075)

increased physiological sensitivity to xenobiotic ( J:68843 , J:131075 )

• following ip injection of kappa-carrageenan at 75 mg/kg, mice exhibit more severe renal damage and dysfunction compared to similarly treated wild-type controls (J:68843)

• however, renal damage induced by cisplatin, bromoethylamine hydrobromide, or glycerol is similar to wild-type controls (J:68843)

• increased severity of concanavalin-A induced hepatic injury compared to similarly treated wild-type controls (J:131075)

renal/urinary system

abnormal kidney inner medulla morphology ( J:68843 )

• on days 2 following ip injection of kappa-carrageenan at 75 mg/kg, mice exhibit extensive deposition of kappa-carrageenan in the inner medulla compared with similarly treated wild-type controls

dilated renal tubule ( J:68843 )

• on days 1 and 4 following ip injection of kappa-carrageenan at 75 mg/kg, surviving mice exhibit more extensive and severe renal tubule dilation than similarly treated wild-type controls

kidney degeneration ( J:68843 )

• on days 1 and 4 following ip injection of kappa-carrageenan at 75 mg/kg, mice exhibit more extensive and severe inner medulla degeneration than similarly treated wild-type controls

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:65874 )

• at E17.5 degeneration of vessels is more diffuse and occurs over a larger area compared to wild-type controls