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Phenotypes Associated with This Genotype
Genotype
MGI:3851906
Allelic
Composition		 Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
7630403G23RikTg(Th-cre)1Tmd/7630403G23Rik+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
7630403G23RikTg(Th-cre)1Tmd mutation (1 available); any 7630403G23Rik mutation (3 available)
Gt(ROSA)26Sortm2(SNCA*119)Djmo mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating noradrenaline level ( J:150777 )
• increased levels of norepinephrine observed in striatum in 10-11 month old mice
decreased dopamine level ( J:150777 )
• 32% reduction in levels of striatal dopamine observed in 10-11 month old mice
increased serotonin level ( J:150777 )
• increased levels of 5-HT observed in prefrontal cortex in 10-11 month old mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Parkinson's disease 1 DOID:0060367 OMIM:168601
 J:150777

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory