Phenotypes Associated with This Genotype

Genotype
MGI:3852220

• Allelic Composition: Gpd2^tm1Tka/Gpd2^tm1Tka; Slc25a13^tm1Lct/Slc25a13^tm1Lct
• Genetic Background: B6.Cg-Gpd2^tm1Tka Slc25a13^tm1Lct

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:124766 )

• 30% fewer than expected mice are found between 20 and 40 days

homeostasis/metabolism

increased aspartic acid level ( J:124766 )

• hepatic aspartic acid levels are higher than in wild-type mice

abnormal circulating amino acid level ( J:124766 )

• citrulline and threonine/serine ratios are higher than in wild-type mice

• following oral sucrose administration, the plasma alanine concentration and branched amino acid/aromatic amino acid ratio are decreased compared to in wild-type mice

increased circulating ammonia level ( J:124766 )

• under fed conditions and after oral sucrose administration

increased blood urea nitrogen level ( J:124766 )

• plasma urea concentrations are higher than in wild-type mice

hypoglycemia ( J:124766 )

• compared to in wild-type mice and more severely than in Slc25a13^tm1Lct homozygotes under fasting and fed conditions

decreased circulating insulin level ( J:124766 )

• compared to wild-type mice and more severely than in Gpd2^tm1Tka homozygotes

increased circulating free fatty acids level ( J:124766 )

increased circulating glycerol level ( J:124766 )

increased circulating alkaline phosphatase level ( J:124766 )

increased liver triglyceride level ( J:124766 )

liver/biliary system

increased liver triglyceride level ( J:124766 )

hepatic steatosis ( J:124766 )

• following 16 hours of fasting

growth/size/body

decreased body weight ( J:124766 )

• by 36 days in males and 29 days in females

postnatal growth retardation ( J:124766 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
citrullinemia		DOID:9273		J:124766