Analysis Tools
behavior/neurological
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• in an amphetamine (1, 3 or 5 mg/kg) conditioned place preference (CPP) paradigm in mice with NAc deletion of dopamine receptor 2 (D2R)-specific striatopallidal neurons, analysis of the extinction of CPP over 1 week showed that mutants maintained greater CPP on days 4 and 9 after last amphetamine injection whereas controls showed loss of CPP on day 9
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• at 6 days after bilateral full striatum diptheria toxin injection, mice show 3 to 4-fold higher activity in the open field; hyperactivity is stable through 16 days post-injection, with hyperactivity still apparent at 33 days
• however, deletion of D2R-striatopallidal neurons in the nucleus accumbens (NAc) by injection of diptheria toxin does not result in spontaneous hyperlocomotion in the mice
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nervous system
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• mesostriatal dopaminergic system after ablation of striatopallidal neurons by diptheria toxin injection was not significantly different from controls in terms of dopamine extracellular concentration or amphetamine-induced dopamine overflow
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• unilateral or bilateral diptheria toxin injection into the striatum causes unilateral or complete loss of dopamine receptor 2 (D2R)-specific striatopallidal neurons at 14 days after injection; neuron loss was similar from the anterior to the posterior striatum
• dopamine receptor 1-specific neurons are unaffected and striatal interneuron populations remain intact
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