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Phenotypes Associated with This Genotype
Genotype
MGI:3852547
cx26
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
Rnf2tm1Mvl/Rnf2tm1Mvl
Genetic
Background		 involves: 129P2/Ola * 129/Sv * C57BL/6J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (66 available)
Rnf2tm1Mvl mutation (0 available); any Rnf2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryonic growth arrest ( J:82399 )
• development does not progress past E11-E12
abnormal somite development ( J:82399 )
• some somites are laid down in paraxial mesoderm which is never observed in Rnf2 homozygotes

nervous system
abnormal forebrain development ( J:82399 )
• abnormal forebrain development with a near complete lack of head mesenchyme

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory