Phenotypes Associated with This Genotype

Genotype
MGI:4353812

• Allelic Composition: Plcb1^tm1Hssh/Plcb1^tm1Hssh
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:151070 )

• in a Morris water maze, standard housed and environmentally enriched mice fail to exhibit a preference for the target quadrant unlike similarly treated wild-type mice

• in a Morris water maze, standard housed exhibit decreased frequency of crossing over the platform and increased latency compared with wild-type mice

decreased startle reflex ( J:151070 )

• mice in standard housing exhibit decreased startle reflex compared with wild-type mice in standard housing

• environmental enrichment fails to decrease startle reflex as in similarly treated wild-type mice

• however, clozapine attenuates startle reflex as in wild-type mice

hyperactivity ( J:151070 )

• mice in standard housing exhibit hyperactivity compared with wild-type mice in standard housing

• however, mice exposed to environmental enrichment exhibit normal activity levels

nervous system

decreased prepulse inhibition ( J:151070 )

• mice in standard housing exhibit decreased prepulse inhibition compared with wild-type mice in standard housing

• however, environmental enrichment or treatment with clozapine rescue prepulse inhibition deficit

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:151070