Phenotypes Associated with This Genotype

Genotype
MGI:4353816

• Allelic Composition: Gt(ROSA)26Sor^{tm2(SNCA*119)Djmo}/Gt(ROSA)26Sor^{tm2(SNCA*119)Djmo}; 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased dopamine level ( J:150777 )

• there are significant reductions in the levels of striatal dopamine (~32%), dihydroxyphenylacetic acid (~46%) and homovanillic acid (~33%) compared to controls at 10-11 months of age

increased noradrenaline level ( J:150777 )

• norepinephrine levels in the striatum are elevated at 10-11 months of age compared to controls

increased serotonin level ( J:150777 )

• 5-HT levels are elevated in the prefrontal cortex at 10-11 months of age compared to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:150777