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Phenotypes Associated with This Genotype
Genotype
MGI:4354208
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(Tyr-BRAF*V600E)476Fgh/0
Genetic
Background		 involves: 129/Sv * C57BL/6J * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Tg(Tyr-BRAF*V600E)476Fgh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:151455 )
• survival is less than in Tg(Tyr-BRAF*V600E)470Fgh mice

neoplasm
increased melanoma incidence ( J:151455 )
• mice develop increased incidence of melanomas with reduced latency and decreased lifespan compared to mice with Tg(Tyr-BRAF*V600E)476Fgh

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
melanoma DOID:1909 J:151455

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory