Analysis Tools
immune system
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• mice have mild splenomegaly resulting from increased cell number
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• marginal zone B cell numbers are reduced about 40%
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• thymocytes have reduced rates of apoptosis in culture
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• B cell proliferation is enhanced to anti-IgM and anti-CD40 but not to LPS
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• T cells hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation
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• thymocytes hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation
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• there is a modest decrease in TGF-beta1 secretion by regulatory T cells
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• IFN-gamma secretion by T cells is doubled after activation compared to controls
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• thymocytes and T cells secrete more IL-2 after activation relative to controls
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• IL-4 production by T cells is doubled after activation compared to controls
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• T cells are resistant to anergy induced by calcium ionophores or CTLA-4 binding
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• increased levels of anti-DNA antibodies are detected in the sera of mice over 5 months of age
• isotypes of antibodies are predominately IgM, IgG2b and IgG3
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• increased levels of anti-histone antibodies are detected in the sera of mice over 5 months of age
• isotypes of antibodies are predominately IgM, IgG2b and IgG3
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• mononuclear cellular infiltrate is observed in mice after 9 months of age
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• diffuse immunoglobulin complexes are observed in the glomeruli of mice
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• mononuclear cellular infiltrate is observed in mice after 9 months of age
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homeostasis/metabolism
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• there is a modest decrease in TGF-beta1 secretion by regulatory T cells
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liver/biliary system
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• mononuclear cellular infiltrate is observed in mice after 9 months of age
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renal/urinary system
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• diffuse immunoglobulin complexes are observed in the glomeruli of mice
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respiratory system
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• mononuclear cellular infiltrate is observed in mice after 9 months of age
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hematopoietic system
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• mice have mild splenomegaly resulting from increased cell number
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• marginal zone B cell numbers are reduced about 40%
|
|
• thymocytes have reduced rates of apoptosis in culture
|
|
• B cell proliferation is enhanced to anti-IgM and anti-CD40 but not to LPS
|
|
• T cells hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation
|
|
• thymocytes hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation
|
|
• there is a modest decrease in TGF-beta1 secretion by regulatory T cells
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cellular
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• thymocytes have reduced rates of apoptosis in culture
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• B cell proliferation is enhanced to anti-IgM and anti-CD40 but not to LPS
|
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• T cells hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation
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endocrine/exocrine glands
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• thymocytes have reduced rates of apoptosis in culture
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• thymocytes hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation
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growth/size/body
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• mice have mild splenomegaly resulting from increased cell number
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