About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4355144
tg3
Allelic
Composition
Tg(Th-Oprm1)4Jtw/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Th-Oprm1)4Jtw mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• activation of the mu-opioid receptor (MOR) by met-enkephalin (ME) induces a hyperpolarization which desensitizes acutely to the same extent as the endogenous receptor in wild-type mice; a 7-fold decrease in the EC50 for ME is observed with the increased receptor expression seen in mutants


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/17/2024
MGI 6.24
The Jackson Laboratory