Phenotypes for Oprm1 Tg(Th-Oprm1)4Jtw MGI:4355145 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Oprm1^tm1Jep/Oprm1^tm1Jep Tg(Th-Oprm1)4Jtw/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1Jep mutation (0 available); any Oprm1 mutation (54 available)
Tg(Th-Oprm1)4Jtw mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:151536 )

• maximum hyperpolarization of neurons induced by met-enkephalin (ME) is similar to that seen in wild-type and transgenic wild-type opioid receptor mutant animals; the EC₅₀ for ME is 50% greater than the transgene-only mutants

• desensitization by ME and recovery of desensitization of receptors is similar to wild-type and transgene-only controls

• desensitization and internalization of the mu-opioid receptor (MOR) in response to various MOR agonists is not different in mutants and controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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