Phenotypes Associated with This Genotype

Genotype
MGI:4355229

• Allelic Composition: Apoe^{tm3(APOE*4)Mae}/Apoe^{tm3(APOE*4)Mae}; Tg(APPSWE)2576Kha/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:98636 )

• increased levels of Amyloid beta 1-40 in cortical extracts at 3 months of age

• increased ratio of Amyloid beta 40:42 in cortical extracts at 3 months of age

• deposition delayed until after 12 months of age

• Amyloid beta deposition starts around 12-15 months of age

• deposition is almost exclusively in cerebral blood vessels with very few parenchymal plaques at 15 months

cerebral amyloid angiopathy ( J:98636 )

• Amyloid beta deposition starts around 12-15 months of age

• deposition is almost exclusively in cerebral blood vessels

abnormal cerebrospinal fluid amyloid beta 40 isoform level ( J:98636 )

• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age

abnormal cerebrospinal fluid amyloid beta 42 isoform level ( J:98636 )

• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age

homeostasis/metabolism

amyloid beta deposits ( J:98636 )

• increased levels of Amyloid beta 1-40 in cortical extracts at 3 months of age

• increased ratio of Amyloid beta 40:42 in cortical extracts at 3 months of age

• deposition delayed until after 12 months of age

• Amyloid beta deposition starts around 12-15 months of age

• deposition is almost exclusively in cerebral blood vessels with very few parenchymal plaques at 15 months

cerebral amyloid angiopathy ( J:98636 )

• Amyloid beta deposition starts around 12-15 months of age

• deposition is almost exclusively in cerebral blood vessels

abnormal cerebrospinal fluid amyloid beta 40 isoform level ( J:98636 )

• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age

abnormal cerebrospinal fluid amyloid beta 42 isoform level ( J:98636 )

• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:98636