nervous system
• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region
|
• plaque deposition in cortical parenchyma increased 20%
• reduced deposition in cerebral microvasculature
• microglia are tightly associated with parenchymal plaque amyloid
|
• increased number of neuroreactive astrocytes in cortex
• decreased number of neuroreactive astrocytes in thalamic region
|
hematopoietic system
• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region
|
immune system
• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region
|
homeostasis/metabolism
• plaque deposition in cortical parenchyma increased 20%
• reduced deposition in cerebral microvasculature
• microglia are tightly associated with parenchymal plaque amyloid
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Alzheimer's disease | DOID:10652 | J:136318 |