Phenotypes Associated with This Genotype

Genotype
MGI:4356437

• Allelic Composition: Del(7Ipw-Snord116)1Jbro/+
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:242655 )

♂ • in the peak procedure task, when anticipating an event, mutants in which the allele is paternally inherited, start responding later than controls, and when terminating the behavior, mutants stop earlier, indicating that mutants use different strategies to time their behavior

♂ • in the switch task test, mutants in which the allele is paternally inherited, enhance their performance by delaying the switching from one location to the other during the light phase, resulting in a reduction of the error rate and indicating altered risk assessment in decision making

♂ • however, time perception is normal

abnormal eating behavior ( J:242655 )

♂ • when the allele is inherited paternally, mice subjected to a timed food schedule in constant darkness significantly postpone their food anticipatory activity compared to controls

increased food intake ( J:242655 )

♂ • overall food intake is increased in mice when the allele is inherited paternally

mortality/aging

postnatal lethality ( J:152022 )

• Background Sensitivity: when this allele is inherited paternally, 15% of mice die during the postnatal period unlike when the background includes FVB/N

cellular

maternal imprinting ( J:242655 )

• the maternal allele is imprinted and silenced

growth/size/body

decreased body weight ( J:152022 )

• when this allele is inherited paternally but not maternally

postnatal growth retardation ( J:152022 )

• by P5 or P6 when this allele is inherited paternally

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Prader-Willi syndrome		DOID:11983	OMIM:176270	J:242655