Phenotypes Associated with This Genotype

Genotype
MGI:4357767

• Allelic Composition: Tg(Vav1-NUP98/HOXD13)G2Apla/0
• Genetic Background: C57BL/6-Tg(Vav1-NUP98/HOXD13)G2Apla

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:107446 )

• animals develop leukemia, myelodysplastic syndrome, or some hematologic abnormality by 14 months

hematopoietic system

abnormal definitive hematopoiesis ( J:107446 )

• peripheral blood cytopenias and dysplasia are observed in clinically healthy mutants at 4 to 7 months

increased nucleated erythrocyte cell number ( J:107446 )

• circulating nucleated red blood cells are seen seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome

anisocytosis ( J:107446 )

• seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome

poikilocytosis ( J:107446 )

• seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome

polychromatophilia ( J:107446 )

• seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome

abnormal neutrophil morphology ( J:107446 )

• hypersegmented neutrophils are seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome

decreased neutrophil cell number ( J:107446 )

• observed in clinically healthy mutants at 4 to 7 months

decreased leukocyte cell number ( J:107446 )

• observed in clinically healthy mutants at 4 to 7 months

decreased lymphocyte cell number ( J:107446 )

• observed in clinically healthy mutants at 4 to 7 months

immune system

abnormal neutrophil morphology ( J:107446 )

• hypersegmented neutrophils are seen in peripheral blood smears from 1 animal dying from progressive myelodysplastic syndrome

decreased neutrophil cell number ( J:107446 )

• observed in clinically healthy mutants at 4 to 7 months

decreased leukocyte cell number ( J:107446 )

• observed in clinically healthy mutants at 4 to 7 months

decreased lymphocyte cell number ( J:107446 )

• observed in clinically healthy mutants at 4 to 7 months

neoplasm

increased leukemia incidence ( J:107446 )

• hematologic abnormalities progress to acute leukemia in a subset of mutants

• some animals develop myeloid leukemia with others developing undifferentiated leukemia characterized by hepatosplenic infiltration of blasts; a few animals develop precursor-T lymphoblastic lymphoma/leukemia (pre-T LBL)

• other mutants develop a myeloproliferative disease-like leukemia with one showing a biphenotypic leukemia with thymic enlargement and hepatosplenomegaly

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
myelodysplastic syndrome		DOID:0050908	OMIM:614286	J:107446