Analysis Tools
mortality/aging
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• following withdrawal of doxycycline, all mice succumb to liver tumors within 2 weeks
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|
• median survival of mutants is 31 weeks following doxycycline withdrawal to induce MYC expression
• median survival of mutants with tumors is 27 weeks following doxycycline withdrawal to induce MYC expression
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neoplasm
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• following withdrawal of doxycycline, mice develop tumors with a latency of 12 weeks and all mice succumb to liver tumors within 2 weeks
(J:93899)
• liver tumors that develop in mice after doxycycline withdrawal are invasive and metastasis into the thoracic cavity and lung parenchyma
(J:93899)
• however, re-establishment of doxycycline-treatment produces rapid and sustained tumor regression
(J:93899)
• repeated withdrawal and treatment with doxycyclineinduces and represses, respectively, tumor formation
(J:93899)
|
|
• liver tumors that develop in mice after doxycycline withdrawal resemble hepatocellular carcinomas and/or hepatoblastomas
|
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• liver tumors that develop in mice after doxycycline withdrawal resemble hepatocellular carcinomas and/or hepatoblastomas
(J:93899)
• tumors that form in mice after doxycycline withdrawal are composed of hepatocellular neoplasms characterized by sheets of cells with occasional mitotic figure, slightly pleomorphic nuclei, and prominent nucleoli
(J:172430)
• tumors show a range of differentiation between well- and moderately-differentiated hepatocellular carcinoma
(J:172430)
• mice develop multifocal hepatocellular carcinoma within 5-8 weeks of age when doxycycline is removed at birth, showing invasive tumor cells in glandular and solid pattern infiltrating adjacent normal liver tissue
(J:186226)
• in doxycycline-treated mice
(J:190067)
• however, treatment with adeno-associated virus-expressing Mir122 suppresses tumorigenesis
(J:190067)
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|
• doxycycline-treated mice infected with an adeno-associated virus-expressing Mir122 exhibit suppression of tumorigenesis tumor cell proliferation compared with control mice
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liver/biliary system
|
• following withdrawal of doxycycline, mice develop tumors with a latency of 12 weeks and all mice succumb to liver tumors within 2 weeks
(J:93899)
• liver tumors that develop in mice after doxycycline withdrawal are invasive and metastasis into the thoracic cavity and lung parenchyma
(J:93899)
• however, re-establishment of doxycycline-treatment produces rapid and sustained tumor regression
(J:93899)
• repeated withdrawal and treatment with doxycyclineinduces and represses, respectively, tumor formation
(J:93899)
|
|
• liver tumors that develop in mice after doxycycline withdrawal resemble hepatocellular carcinomas and/or hepatoblastomas
|
|
• liver tumors that develop in mice after doxycycline withdrawal resemble hepatocellular carcinomas and/or hepatoblastomas
(J:93899)
• tumors that form in mice after doxycycline withdrawal are composed of hepatocellular neoplasms characterized by sheets of cells with occasional mitotic figure, slightly pleomorphic nuclei, and prominent nucleoli
(J:172430)
• tumors show a range of differentiation between well- and moderately-differentiated hepatocellular carcinoma
(J:172430)
• mice develop multifocal hepatocellular carcinoma within 5-8 weeks of age when doxycycline is removed at birth, showing invasive tumor cells in glandular and solid pattern infiltrating adjacent normal liver tissue
(J:186226)
• in doxycycline-treated mice
(J:190067)
• however, treatment with adeno-associated virus-expressing Mir122 suppresses tumorigenesis
(J:190067)
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| colorectal cancer | DOID:9256 |
OMIM:114500 |
J:190067 | |
| hepatocellular carcinoma | DOID:684 |
OMIM:114550 |
J:93899 , J:172430 , J:186226 | |
