Phenotypes Associated with This Genotype

Genotype
MGI:4358249

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:212219 )

♂N • mice survive at least 1 year

reproductive system

enlarged prostate gland anterior lobe ( J:170965 )

♂

increased prostate gland weight ( J:170965 )

♂

prostate gland hyperplasia ( J:170965 )

♂

increased prostate gland tumor incidence ( J:170965 , J:172730 , J:268934 )

♂ • mice exhibit microinvasive tumors in the prostate gland unlike in Pdpk1^tm1Dral homozygotes (J:170965)

♂ • mutants develop castrate-resistant prostate cancer (J:172730)

♂ • mice develop intracystic prostatic carcinomas between 4 and 10 months of age (J:268934)

increased prostate gland adenocarcinoma incidence ( J:184935 , J:212219 , J:268934 )

♂ • mice predominately develop adenocarcinoma localized to the dorsolateral lobes of the prostate (J:184935)

♂ • localized lesions that slowly progress to prostate adenocarcinomas (J:212219)

♂ • 4 of 8 mice develop prostatic adenocarcinoma and 3 of 8 mice exhibit invasive carcinomas after 10 months (J:268934)

increased prostate intraepithelial neoplasia incidence ( J:131932 , J:212219 , J:268934 )

♂ • in lesions, basal cells are not disorganized in contrast to Tg(Pbsn-ERG*)1Vv mice at 7 weeks (J:131932)

♂ • localized lesions that slowly progress to prostate adenocarcinomas (J:212219)

♂ • 4 of 4 mice develop low grade pancreatic intraepithelial neoplasia (PIN) and 2 of 4 mice show multifocal high grade PIN before 4 months of age (J:268934)

♂ • 6 of 6 mice exhibit multifocal high grade PIN at 4-10 months of age (J:268934)

neoplasm

increased prostate gland tumor incidence ( J:170965 , J:172730 , J:268934 )

♂ • mice exhibit microinvasive tumors in the prostate gland unlike in Pdpk1^tm1Dral homozygotes (J:170965)

♂ • mutants develop castrate-resistant prostate cancer (J:172730)

♂ • mice develop intracystic prostatic carcinomas between 4 and 10 months of age (J:268934)

increased prostate gland adenocarcinoma incidence ( J:184935 , J:212219 , J:268934 )

♂ • mice predominately develop adenocarcinoma localized to the dorsolateral lobes of the prostate (J:184935)

♂ • localized lesions that slowly progress to prostate adenocarcinomas (J:212219)

♂ • 4 of 8 mice develop prostatic adenocarcinoma and 3 of 8 mice exhibit invasive carcinomas after 10 months (J:268934)

increased prostate intraepithelial neoplasia incidence ( J:131932 , J:212219 , J:268934 )

♂ • in lesions, basal cells are not disorganized in contrast to Tg(Pbsn-ERG*)1Vv mice at 7 weeks (J:131932)

♂ • localized lesions that slowly progress to prostate adenocarcinomas (J:212219)

♂ • 4 of 4 mice develop low grade pancreatic intraepithelial neoplasia (PIN) and 2 of 4 mice show multifocal high grade PIN before 4 months of age (J:268934)

♂ • 6 of 6 mice exhibit multifocal high grade PIN at 4-10 months of age (J:268934)

increased metastatic potential ( J:268934 )

♂ • prostate cancer metastasis after 10 months of age, with 12.5% of mice showing metastatic lesions to lungs and lymph nodes

increased carcinoma incidence ( J:268934 )

♂ • 2 of 6 mice develop intracystic prostatic carcinomas between 4 and 10 months of age

♂ • 6 of 8 mice show intracystic prostatic carcinoma after 10 months of age

endocrine/exocrine glands

enlarged prostate gland anterior lobe ( J:170965 )

♂

increased prostate gland weight ( J:170965 )

♂

prostate gland hyperplasia ( J:170965 )

♂

increased prostate gland tumor incidence ( J:170965 , J:172730 , J:268934 )

♂ • mice exhibit microinvasive tumors in the prostate gland unlike in Pdpk1^tm1Dral homozygotes (J:170965)

♂ • mutants develop castrate-resistant prostate cancer (J:172730)

♂ • mice develop intracystic prostatic carcinomas between 4 and 10 months of age (J:268934)

increased prostate gland adenocarcinoma incidence ( J:184935 , J:212219 , J:268934 )

♂ • mice predominately develop adenocarcinoma localized to the dorsolateral lobes of the prostate (J:184935)

♂ • localized lesions that slowly progress to prostate adenocarcinomas (J:212219)

♂ • 4 of 8 mice develop prostatic adenocarcinoma and 3 of 8 mice exhibit invasive carcinomas after 10 months (J:268934)

increased prostate intraepithelial neoplasia incidence ( J:131932 , J:212219 , J:268934 )

♂ • in lesions, basal cells are not disorganized in contrast to Tg(Pbsn-ERG*)1Vv mice at 7 weeks (J:131932)

♂ • localized lesions that slowly progress to prostate adenocarcinomas (J:212219)

♂ • 4 of 4 mice develop low grade pancreatic intraepithelial neoplasia (PIN) and 2 of 4 mice show multifocal high grade PIN before 4 months of age (J:268934)

♂ • 6 of 6 mice exhibit multifocal high grade PIN at 4-10 months of age (J:268934)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:172730 , J:184935