Phenotypes Associated with This Genotype

Genotype
MGI:4358348

cx7

• Allelic Composition: Hoxa5^tm1Rob/Hoxa5^tm1Rob; Hoxb5^tm1Mrc/Hoxb5^tm1Mrc; Hoxc5^tm1Mrc/Hoxc5^tm1Mrc
• Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal axial skeleton morphology ( J:124112 )

• the clavicles are attached to the rib cage by connective tissue and do not articulate directly with it unlike in wild-type mice

absent sternal manubrium ( J:124112 )

short sternum ( J:124112 )

abnormal rib joint morphology ( J:124112 )

• a eighth rib is attached to the sternum unlike in wild-type mice

• T1 ribs exhibit incomplete projection and T2 ribs extend but often do not reach the sternum (in 64% of mice)

• however, rib attachment posterior to T1 is normal

abnormal rib development ( J:124112 )

• ribs initiate but do not extend on T1 unlike in wild-type mice

decreased rib number ( J:124112 )

• mice are missing a complete first rib

rib fusion ( J:124112 )

• rib 2 and 3 are fused prior to attachment to the sternum

small thoracic cage ( J:124112 )

abnormal intervertebral disk morphology ( J:124112 )

• dorsal cartilage is thickened and forms a distinct curvature at the top of the vertebra unlike in wild-type mice

cervical vertebral fusion ( J:124112 )

vertebral transformation ( J:124112 )

• C3 through T2 exhibit anterior homeotic transformations

• C3 through T1 exhibit characteristics of C2

• however, posterior thoracic, lumbar, and sacral vertebrae are normal in appearance and position

thoracic vertebral transformation ( J:124112 )

• C3 through T1 exhibit characteristics of C2

• T2 lacks anterior projections and is similar to T3

• ibs do not extend on T1 unlike in wild-type mice

cervical vertebral transformation ( J:124112 )

• C3 through T1 exhibit characteristics of C2

• vertebral foramina extend beyond C6 to C7 unlike in wild-type mice