Phenotypes for Ncoa1 Thra MGI:4358584 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ncoa1^tm1Bwo/Ncoa1^tm1Bwo Thra^tm2Jas/Thra^tm2Jas
Genetic Background	B6.129-Thra^tm2Jas Ncoa1^tm1Bwo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa1^tm1Bwo mutation (0 available); any Ncoa1 mutation (169 available)
Thra^tm2Jas mutation (1 available); any Thra mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating thyroxine level ( J:126521 )

increased circulating triiodothyronine level ( J:126521 )

decreased circulating thyroid-stimulating hormone level ( J:126521 )

• after a low-iodine diet and propylthiouracil, TSH serum levels increase to 50% of wild-type

increased circulating thyroid-stimulating hormone level ( J:126521 )

abnormal response/metabolism to endogenous compounds ( J:126521 )

• after a low-iodine diet and propylthiouracil and L-T3, mice exhibit mild resistance to thyroid hormone compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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