Phenotypes Associated with This Genotype

Genotype
MGI:4358724

• Allelic Composition: Dtnbp1^sdy/Dtnbp1^sdy
• Genetic Background: DBA/2J-Dtnbp1^sdy/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

diluted coat color ( J:14267 )

decreased eye pigmentation ( J:14267 )

• pink eyes

behavior/neurological

abnormal behavioral response to amphetamine ( J:143912 )

♂ • mice exhibit a smaller increase in locomotor activity following acute amphetamine treatment compared to wild-type mice

♂ • following an amphetamine challenge, a significant increase in the locomotor activity is seen in amphetamine pre-treated mutants compared to amphetamine pre-treated wild-type mice

enhanced cued conditioning behavior ( J:143912 )

♂ • mutants exhibit increased freezing to an auditory tone compared to wild-type controls, suggesting enhanced amygdala-related fear memory

♂ • however, contextual memory appears to be intact

abnormal habituation to a new environment ( J:143912 )

♂ • mutants do not show a decrease in locomotor activity from day 1 to day 7 in a novel environment, indicating lack of habituation to the environment that is seen in wild-type mice

impaired short-term object recognition memory ( J:143912 )

♂ • after 5 min of retention interval, mutants spend less time exploring a new object compared to controls indicating impaired short-term object recognition memory

hypoalgesia ( J:143912 )

♂ • mutants take more time in removing their paw from a high intensity beam indicating less sensitivity to thermal nociception

vision/eye

decreased eye pigmentation ( J:14267 )

• pink eyes

homeostasis/metabolism

increased bleeding time ( J:14267 )

integument

diluted coat color ( J:14267 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:143912