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Phenotypes Associated with This Genotype
Genotype
MGI:4359169
Allelic
Composition		 Npc1m1N/Npc1m1N
Nr1h2tm1Djm/Nr1h2tm1Djm
Genetic
Background		 involves: 129S6/SvEvTac * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npc1m1N mutation (3 available); any Npc1 mutation (74 available)
Nr1h2tm1Djm mutation (3 available); any Nr1h2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:130969 )
• mice die between 60 and 90 days of age from neurodegenerative disease, which is significantly faster than Npc1 mutants on a wild-type background

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Niemann-Pick disease DOID:14504 J:130969

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory